Regenerative Orthopedics and Sports Medicine
Orthobiologics are rapidly becoming indispensable to improve patient outcomes in a variety of orthopedic disorders. Join us to stay abreast of the developments on the role of orthobiologics for the treatment of musculo-skeletal disorders. Learn about the preparation, content, biologic effect and delivery method of various orthobiologics. Discover the therapeutic potential of intra-articular and intra-osseous delivery of Platelet Rich Plasma (PRP), Bone Marrow Aspirate Concentrate (BMAC), Stromal Vascular Fraction (SVF) and Mesenchymal Stem Cells (MSC) for the treatment of focal cartilage lesions, osteoarthritis, bone marrow lesions and avascular necrosis. Stay up to date on the effects of orthobiologics on knee ligament reconstructions, meniscal healing, hip preservation surgery, rotator cuff repairs. Find out evidence based recommendations on the role of orthobiologics for the treatment of muscle injuries, insertional tendinopathies, and overuse injuries in sports
Wound Care and Regenerative Medicine
Regenerative and Aesthetic Gynecology
Stem cell research and regenerative medicine are integral to the field of Obstetrics and Gynecology. With the explosion of technologies directed at treatments for infertility, there is a critical need to understand properties of pluripotency and how it relates to embryo development. Evidence of cancer stem cells will drive new discoveries in the treatment of gynecologic malignancies such as ovarian and endometrial cancers.
Notably, there is great interest in regeneration of aged or damaged tissues specific to the female anatomy and lower urinary tract via stem cell-based technologies. In humans, damaged tissues are generally replaced by continuous recruitment and differentiation from stem cells in the body. However, the body’s ability for regeneration is reduced with aging.
Examples of conditions in need of regenerative therapies are urinary and fecal incontinence resulting from sphincter deficiency and pelvic organ prolapse. These conditions are prevalent in older women and greatly affect quality of life and represent colossal health costs. Current approaches for tissue regeneration include transplantation of adult mesenchymal cells or their derivatives and implantation of engineered scaffolds seeded with these cells. Induced pluripotent stem cells are a promising source of autologous cells. Because of their property of self-renewal, large amounts of cells can be produced for transplantation. Furthermore, their pluripotent state allows for derivation of multiple cell types thus facilitating implementation in a stepwise fashion from simple cell injections to more elaborate matrices with multiple cell types that have potential for full regeneration.
Regenerative Dermatology and Hair Restoration
Skin is an attractive model organ to test novel concepts of regenerative medicine, with a particular emphasis on skin regeneration for acute or chronic wounds. Chronic wounds present a worldwide growing health and economic problem because of a steadily increasing number of patients, high morbidity and risk of amputations, unsatisfactory results of existing therapies and heavy socioeconomic burden.
Tissue-engineered skin substitutes represent an innovative therapeutical option for the treatment of acute and chronic skin wounds. Bioengineered skin replacements are not only supposed to substitute the major physiological functions by providing a rapid and reliable cover of the defect but also should be easily applicable under routine use conditions and reduce pain and discomfort for the patient.
Furthermore, they should elicit the regeneration process from the wound bed without causing inflammation or rejection. Skin substitutes should be available immediately and be non-toxic nor immunogenic. From an aesthetic point of view, skin substitutes should be durable, elastic, with minimized scar formation, and pigmentation should resemble natural skin
Basic Science in Regenerative Medicine
Regenerative medicine is the branch of medicine that develops methods to regrow, repair or replace damaged or diseased cells, organs or tissues. Regenerative medicine includes the generation and use of therapeutic stem cells, tissue engineering and the production of artificial organs.
Aging is an inevitable process that leads to the reduction of function of all tissues and body organs. Platelet Rich plasma and stem cells have shown promising results for rejuvenating and reversing the aging and disease processes in the urinary and reproductive tract organs of both males and females. Erectile dysfunction, Peyronie’s disease, infertility and urinary incontinence remains to be the most challenging conditions for urology and andrology doctors.
Our urology panel members are continually exploring Regenerative methods in urology to provide the best and safest treatment modalities to our patients. Scientists and researchers are greatly encouraged to join us and further enhance our knowledge and expertise.
Stem cells or mother or queen of all cells are pluripotent and have the remarkable potential to develop into many different cell types in the body. Serving as a sort of repair system for the body, they can theoretically divide without limit to replenish other cells as long as the person or animal is alive. When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.
Plastic Surgery and Regenerative Medicine
Regenerative medicine is the science of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal form and function.
This broadly encompasses the use of cells, tissues, drugs, synthetic biomaterials and devices to help patients heal more effectively from trauma, cancer therapy, other disease processes and birth anomalies.
Regenerative medicine therapies can have goals of both healing damaged tissues and forming new tissue.