The restoration of damaged articular cartilage remains one of the biggest challenges in modern clinical orthopaedics. There is no pharmacological treatment that promotes the repair of the cartilage, and conservative modalities inevitably lead to the development of premature osteoarthritis. Current treatment options include bone marrow stimulating techniques (microfracture and nanofracture), matrix-assisted autologous chondrocyte implantation (MACI), and transplantation of ostechondral grafts, each having their own benefits and shortcomings.

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