Orthobiologics have advanced at a rapid pace to influence clinical musculoskeletal care. Musculoskeletal burden of disease is ever enlarging with inadequate, often invasive measures with varying outcomes like Joint Replacement. . With population growth and aging, this presents an economic and practical burden on the health care system of a country. Orthobiologics present an powerful opportunity to manage, and potentially prevent musculoskeletal disease progression, with non-operative, minimally invasive therapies, possibly preventing major joint replacement surgery, as well as to augment surgery like tendon and ligament repairs and to augment fusions. There is a diversity of orthobiologics to use in regenerative medicine with varying degrees of evidence, and a deepening degree of mismarketing and misrepresentation that must be addressed for each. Industry and providers must be able to synthesize the evidence in order to best choose the best orthobiologics for clinical use.
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