Articular cartilage is frequently damaged by trauma and in joint disease but shows only a limited capacity for repair. If focal cartilage lesions are left untreated or are treated inadequately, they progress to more extensive secondary osteoarthritic lesions. The frequent outcome for arthritis in large joints such as the knee is surgical intervention for joint replacement. A joint replacement tends to be successful in older sedentary patients but the limited lifetime of prostheses makes it much less desirable for younger and more active patients.

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